{"id":731,"date":"2022-02-17T12:58:14","date_gmt":"2022-02-17T01:58:14","guid":{"rendered":"https:\/\/www.alignedstudy.org.au\/?page_id=731"},"modified":"2022-03-24T16:11:17","modified_gmt":"2022-03-24T05:11:17","slug":"why-aligned","status":"publish","type":"page","link":"https:\/\/www.alignedstudy.org.au\/index.php\/why-aligned\/","title":{"rendered":"Why ALIGNED?"},"content":{"rendered":"\t\t
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When might the ALIGNED trial be suitable?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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The following examples illustrate potential scenarios where this trial* may help a person who requires medication to treat depression<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t*All participants in the ALIGNED trial will undergo pharmacogenomics testing. However, as this trial is a double-blind randomised controlled study, only those participants randomised to the intervention group will have their antidepressant treatment tailored to pharmacogenomics, whereas those randomised to the control group will receive standard antidepressant treatment, for the first three months. At week 12, every participant will receive a copy of their pharmacogenomics report through their GP, after which, the participants have the discretion of whether to discuss the report with their treating physician and\/or use it to plan their ongoing treatment. \t\t\t<\/p>\n\t\t\t\t\t<\/blockquote>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tFurther details about the ALIGNED trial<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Carol is a 35-year-old professional artist who is previously well with no medical or mental health history. <\/strong><\/p>

Carol develops depression during the COVID pandemic lockdown. As she has never taken regular medications and is generally averse to taking any pharmacotherapy, Carol is hesitant when her GP mentions antidepressant therapy. Carol opts to trial psychology counselling support before starting antidepressant treatment if her symptoms do not improve. After six sessions with the psychologist, Carol returns to see her GP to discuss starting an antidepressant. Carol has come across pharmacogenomics in her reading about depression treatment and feels more confident in taking medication that is tailored to her genetic makeup. Carol discusses testing with her GP to personalise antidepressant therapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Charlie is a 28-year-old non-binary mature-aged University student who is studying law and has a strong family history of mental distress. <\/strong><\/p>

Charlie\u2019s older brother did not respond to medications for severe depression and ended up in hospital for a long time, and Charlie\u2019s aunt and cousin have been diagnosed with bipolar affective disorder. Charlie develops symptoms of depression, however, as the GP is not confident to exclude bipolar disorder, Charlie is referred to a psychiatrist. The psychiatrist diagnoses Charlie with Major Depressive Disorder. Charlie is keen to determine the best treatment as soon as possible to minimise disruption to their study. The psychiatrist considers pharmacogenomics to individualise drug choice and dosing to optimise Charlie\u2019s chance of response and recovery.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Alex is a 56-year-old computer programmer who has a history of recurrent depression. <\/strong><\/p>

He has trialled many different antidepressants in the past and while some helped, he disliked taking them due to significant adverse effects. He experiences another episode of depression triggered by relationship breakdown. He sees his GP, who discusses pharmacogenomics testing with Alex to better guide drug therapy to improve medication tolerability.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

When might the ALIGNED trial be suitable? The following examples illustrate potential scenarios where this trial* may help a person who requires medication to treat depression *All participants in the ALIGNED trial will undergo pharmacogenomics testing. However, as this trial is a double-blind randomised controlled study, only those participants randomised to the intervention group will […]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":"","footnotes":""},"class_list":["post-731","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/pages\/731","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/comments?post=731"}],"version-history":[{"count":16,"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/pages\/731\/revisions"}],"predecessor-version":[{"id":843,"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/pages\/731\/revisions\/843"}],"wp:attachment":[{"href":"https:\/\/www.alignedstudy.org.au\/index.php\/wp-json\/wp\/v2\/media?parent=731"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}